SEFNIN
Cephradine BP
COMPOSITION
Sefnin 250 Capsule: Each capsule contains Cephradine BP 250 mg.
Sefnin 500 Capsule: Each capsule contains Cephradine BP 500 mg.
Sefnin Dry Suspension: After reconstitution each 5 ml suspension contains Cephradine BP 125 mg.
CLINICAL INFORMATION
Therapeutic Indications
Sefnin (Cephradine) is used in the treatment of infections caused by sensitive organisms.
- Upper respiratory tract infections: Pharyngitis, sinusitis, otitis media, tonsilitis, laryngotracheo-bronchitis.
- Lower respiratory tract infections: Acute and chronic bronchitis, lobar and bronchopneumonia.
- Urinary tract infections: Cystitis, urethritis, pyelonephritis. Skin and soft tissue infections: Abscess, cellulitis, furunculosis, impetigo.
- Gastrointestinal tract infections: Bacillary dysentery, enteritis, peritonitis.
- Bone and joint infection.
- Surgical prophylaxis: It is also used in preoperative prophylactic
administration (pre-operatively, intra-operatively and post-
operatively). In cesarean section, intra-operative (after clamping the umbilical cord) and post-operative use may reduce the incidence of certain post-operative infections.
Dosage And Administration
The dosage may be given without regard to meals.
Adult:
Oral: The usual dose is 1-2 gm daily in 2 to 4 divided doses. In severe and prolonged infection, the dose can be increased up to 4 gm daily which should be taken in equally divided doses.
Special dose in the following infections: Skin and Skin structures and respiratory tract infections: Usual dose is 250 mg every 6 hours or 500 mg every 12 hours.
Lobar pneumonia: 500 mg every 6 hours or 1 gm every 12 hours.
Urinary tract infection: Usual dose is 500 mg every 12 hours.
Gastro-intestinal tract infection: 500 mg three to four times daily.
Children:
Oral: The usual total dose is 25 to 50 mg/kg/day given in 2 to 4 equally divided doses.
Dose in renal impairment:
In patients with impaired renal function, doses and frequency of administration of Sefnin ® must be modified according to the degree of impairment, severity of infection, susceptibility of the causative organism and serum concentration of the drug. For adults, a loading dose of 750 mg should be given subsequently followed by 500 mg with the mentioned time interval.
Creatinine clearance (ml/min) |
Time interval (hrs.) |
>20 |
6-12 |
15-19 |
12-24 |
10-14 |
24- 40 |
5-9 |
40-50 |
<5 |
50-70 |
For children, dosage schedule may need to be adjusted.
Undiserable Effects
Side effects include nausea, vomiting, diarrhoea and abdominal discomfort. Allergic reactions including skin rashes, urticaria, eosinophilia, angioedema and anaphylaxis may occur and elevation of hepatic enzyme values have been noted. Neutropenia has been reported.
Super-infection with resistant microorganisms, particularly candida, may follow the treatment. There is also a possibility of development of pseudomembranous colitis.
Use In Pregnancy And Lactation
Although there have been no reports of adverse effect on the fetus, safety of use during pregnancy has not been definitely established. The drug should be used during pregnancy only when clearly indicated. Cephalosporins are distributed into breast milk and the drug should be used with caution in nursing women.
Contraindication
It should not be used in patients hypersensitive to any cephalosporin antibiotic.
PHARMACOLOGICAL INFORMATION
Storage & Conditions
Store in cool and dry place, away from light. Keep out of reach of children.
Presentation & Packaging
Sefnin 250 Capsule: Box containing 4x4's, 6x4's, 8x4's Capsules in Alu-Alu /blister Pack.
Sefnin 500 Capsule: Box containing 4x4's, 6x4's, 8x4's Capsules in Alu-Alu blister Pack.
Sefnin Dry Suspension: Each amber glass bottle contains dry powder for 100 ml suspension.
